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Old 12-06-09, 07:18 AM
Yarrgh Yarrgh is offline

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Re: Bupropion HCl and Amphetamine combination produces a neutral affect?

Amphetamines actually have a significantly more complex pharmacodynamic than just binding to DAT transporters and stimulating the release of NA and DA from the presynaptic terminal.

Regardless, all you need to know is that DA and NA are stimulated by amphetamines.

Bupropion inhibits the reuptake of these.

Therefore, not only are you preventing them from being cleared from the synaptic cleft, you are increasing the amount released into it.

It's pretty clear that this should have a synergistic effect. Its fairly likely that bupropion may potentiate amphetamines.
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