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Old 12-24-11, 02:32 PM
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Re: The Holy Grail? -Desoxyn Journal

I posted this as a separate thread for maximum exposure, because I'm very interested in seeing what people think.


A great deal of research has led me to conclude that Desoxyn (dextromethamphetamine) is, indeed, more likely to cause neurotoxicity at prescribed doses than other amphetamines.

Technically, Dexedrine (dextroamphetamine) is the amphetamine with the lowest risk of neurotoxicity. Why? Because it induces less Norepinephrine agonism than Adderall (amphetamine/dextroamphetamine mixed salts) and less Serotonin agonism than Desoxyn. Dopamine agonism does not seem to be nearly as harmful. Our brains are more likely to repair dimished dopamine than serotonin.

Methylphenidate is strictly a reuptake inhibitor, which has actually been found to be neuroprotective. I have read that taking a dose of Methylphenidate after your amphetamine will help to prevent potential amphetamine induced neurotoxicity.

Desoxyn's higher potential for neurotoxicity seems to be directly related to it's Serotonin agonism. Taking methylphenidate (a DNRI) after Desoxyn will help to prevent the depletion of dopamine. So...

I'm wondering if taking an SSRI (like Celexa, which I take currently) helps to prevent any potential neurotoxicity caused by Desoxyn's serotonin agonism. Will an SSRI have neuroprotective effects similar to those which methylphenidate has, only with serotonin?

Anyone know?
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